February 4, 2010 - William Giannobile
Part 1: New and Emerging Concepts in Periodontal Tissue Engineering
Repair of alveolar bone defects caused by development abnormalities, trauma or disease is a major goal of oral reconstructive therapy. The field of tissue engineering combines advances in materials science and biology to repair tissues and organs. Periodontal and peri-implant tissue engineering has been achieved with limited success by the utilization of barrier membranes and block grafting techniques. Over the past decade investigators have begun to utilize growth factors to restore lost tooth support due to damage of the alveolus. This presentation will review emerging therapies in biomaterials, growth factor biology and cell/gene therapy with particular emphasis on recent clinical trial results using recombinant human platelet-derived growth factor (PDGF) and bone morphogenetic proteins (BMP's). The presentation will conclude with a future perspective on the use of novel biomimetic approaches and interactive regenerative materials for oral tissue engineering of defects around teeth and dental implants
Part 2: Implications of Bone Regenerative Biology on Periodontal Medicine
For nearly 100 years, it has been known that oral health can affect systemic well-being. However, it has not been until the past decade, that mounting evidence has revealed the strong inter-relationships among oral disease and systemic disease and in particular the maintenance of oral bone mass. This presentation will highlight research on the etiology and pathogenesis of oral infection and how it can affect systemic bone volume including osteoporosis and osteopenia. The utilization of "bone-sparing" agents to preserve alveolar bone following regenerative therapy or in blocking progressive bone loss will be presented. The utilization of the variety of approaches including inhibitors of MMPs, osteoclasts and pro-inflammatory cytokines will be presented.
Dr. William Giannobile a William K. and Mary Anne Najjar Endowed Professor, Dentistry and Biomedical Engineering and the Director of the Michigan Center for Oral Health Research at the University of Michigan School of Dentistry. He received is DDS and an MS in Oral Biology from the University of Missouri. He later received his Certificate in Periodontology and Doctor of Medical Sciences in Oral Biology from Harvard University. He subsequently completed postdoctoral training in Molecular Biology at the Dana-Farber Cancer Institute and Harvard Medical School. Dr. Giannobile previously served as a faculty member at Harvard and the Forsyth Institute in Boston. He recently completed a sabbatical as a Visiting Professor at the Biotechnology Institute of Regenerative Medicine at the University of Genova Medical School in Genova, Italy and at the School of Dentistry at the University of Milan. Dr. Gionnobile has published over 125 manuscripts, textbook chapters and abstracts and has lectured extensively in the area of Periodontal Regenerative Medicine and Tissue Engineering. Dr. Giannobile is an Associate Editor for the Journal of Periodontolgy, The Public Library of Science (PLoS ONE) and is on the editorial boards of the Journal of Periodontal Research, International Journal of Oral & Maxillofacial Implants and the International Journal of Periodontics & Restorative Dentistry. He also serves as a consultant to the Food and Drug Administration the National Institutes of Health and several biotechnology companies focused on regenerative medicine. Dr. Giannobile is a Diplomate of the American Board of Periodontology and maintains a private practice limited to periodontics and implantology at the University.
April 30, 2010 - Myron Nevins
The predictability offered by osseointegration has created the need for guidelines to delineate the decision-making process of whether to retain the natural teeth or replace them with implants. It is, therefore, omnipotent to decide the prognosis of periodontal regeneration for the teeth in question. Therefore, this program will focus on bone regeneration and the introduction of signaling devices (growth factors) to empower our results. Recognizing the array of popular products that are available and the comfort zone we have created for out therapeutics, why consider a change in paradigm? Because scientific advancement is routinely accompanied by reexamining our cherished beliefs, we need to evaluate our base of information objectively when applying osteoconductive materials, or their combination, to achieve the optimal result from regenerative treatment regimes. This presentation will expand the utilization of growth factors to prepare implant sites including extraction wounds, sinus floor elevation and vertical bone augmentation.
Myron Nevins, D.D.S. is the editor of the International Journal of Periodontics and Restorative Dentistry and Associate Clinical Professor of Periodontology at the Harvard School of Dental Medicine. Dr. Nevins is a past President of the American Academy of Periodontology where his contributions have been recognized with the Gold Medal and The Master Clinician Awards. He is a Professor of Periodontics at the University of Pennsylvania School of Dental Medicine, a Clinical Professor at the Temple University School of Dentistry and Adjunct Professor at the University of North Carolina. He maintains a private practice limited to Periodontics and Implantology in Swampscott, MA.
November 5, 2010 - Paul A. Fugazzotto
Regenerative and implant therapies afford unmatched opportunities for providing previously undreamt of patient treatment outcomes. In order to maximize the benefits of such therapies, it is imperative that the conscientious clinician recognize the indications, contradictions and limitations of various treatment approaches, as well as how best to incorporate these therapies into existing armamentaria. All treatment must be grounded in comprehensive diagnosis, treatment planning and case work up.
Designed to underscore the inter-relationships between the various specialties and the restorative dentist, this course includes a framework in which to carry out differential diagnosis and compresengive treatment planning; periodontal restorative inter-relationships; and various esthetic procedures. The rose of guided bone regeneration, sinus augmentation and implant therapy in the treatment of a variety of patients will be discussed. The indications sinus grafting will be reviewed. And long-term results will be examined. The realistic use of osteotomes and other techniques to simplify therapy will be discussed in detail, culminating in a mathematically based system for treatment approach selection and augmentation of the posterior maxilla.
Guided bone regeneration will be discussed in detail. Diagnostic and technical prerequisites for maximization of the regenerative treatment outcomes will be reviewed, and the results of over 3500 cases will be discussed. Numerous pre and postoperative clinical examples will be examines critically. A clinically based hierarch of implant selection and utilization will be explored and critically examined. The role of immediate insertion and/or immediate load implant therapy in every day proactive will be highlighted, focusing upon treatment planning, surgical restorative interrelationships, and various implant options and approaches in different clinical situations.
Finally, the use of newer technologies in the diagnosis and delivery of implant therapy, both in non-immediate load cases and in full arch immediate load situations, will be discussed in detail. The use of the ICAT machine or other CAT scanning imaging systems, in conjunction with various treatment planning and tent generating computer softwares will be explored. The advantages and disadvantages of each system in various situations will be critically appraised.
February 11, 2011